A Triple-Modal Contrastive Learning Framework with Sequence, Graph, and 3D Features for Drug-Target Interaction Prediction

Accurate prediction of drug-target interactions (DTI) is critical for drug discovery. Existing methods often rely on single-modal representations (e.g., sequences or graphs) or combine only two modalities, overlooking 3D structural features. To address this challenge, we propose TriMod-DTI, a triple-modal contrastive learning framework that incorporates 1D sequences, 2D graphs, and 3D structures of drugs and proteins, obtaining the universal and complementary feature representations for DTI prediction. We design a Feature Extractor to capture drug and target features across the three modalities, thereby enriching their representations. We further propose a triple-modal contrastive learning strategy to align different modal representations of the same drug or protein in the latent space. By constructing cross-modal positive and negative sample pairs, this approach enhances the model's discriminative ability. Experiments on three benchmark datasets demonstrate that TriMod-DTI outperforms state-of-the-art methods. The ablation studies validate the contributions of each modality. Moreover, case studies highlight its practical potential for DTI prediction and drug discovery.

MAGE: Safeguarding LLM Agents against Long-Horizon Threats via Shadow Memory

As large language model (LLM)-powered agents are increasingly deployed to perform complex, real-world tasks, they face a growing class of attacks that exploit extended user-agent-environment interactions to pursue malicious objectives improbable in single-turn settings. Such long-horizon threats pose significant risks to the safe deployment of LLM agents in critical domains. In this paper, we present MAGE (Memory As Guardrail Enforcement), a novel defensive framework designed to counter a wide range of long-horizon threats. Inspired by the "shadow stack" abstraction in systems security, MAGE maintains a dedicated, safety-focused agentic memory that distills and retains safety-critical context across the agent's full execution trajectory, leveraging this shadow memory to proactively assess the risk of pending actions prior to their execution. Extensive evaluation demonstrates that MAGE substantially outperforms existing defenses across diverse long-horizon threats in detection accuracy, achieves early-stage detection for the majority of attacks, and introduces only negligible overhead to agent utility. To our best knowledge, MAGE represents the first framework to detect and mitigate long-horizon threats using an agentic memory approach, establishing a new paradigm for this critical challenge and opening promising directions for future research.

ProVG: Progressive Visual Grounding via Language Decoupling for Remote Sensing Imagery

Remote sensing visual grounding (RSVG) aims to localize objects in remote sensing imagery according to natural language expressions. Previous methods typically rely on sentence-level vision-language alignment, which struggles to exploit fine-grained linguistic cues, such as \textit{spatial relations} and \textit{object attributes}, that are crucial for distinguishing objects with similar characteristics. Importantly, these cues play distinct roles across different grounding stages and should be leveraged accordingly to provide more explicit guidance. In this work, we propose \textbf{ProVG}, a novel RSVG framework that improves localization accuracy by decoupling language expressions into global context, spatial relations, and object attributes. To integrate these linguistic cues, ProVG employs a simple yet effective progressive cross-modal modulator, which dynamically modulates visual attention through a \textit{survey-locate-verify} scheme, enabling coarse-to-fine vision-language alignment. In addition, ProVG incorporates a cross-scale fusion module to mitigate the large-scale variations in remote sensing imagery, along with a language-guided calibration decoder to refine cross-modal alignment during prediction. A unified multi-task head further enables ProVG to support both referring expression comprehension and segmentation tasks. Extensive experiments on two benchmarks, \textit{i.e.}, RRSIS-D and RISBench, demonstrate that ProVG consistently outperforms existing methods, achieving new state-of-the-art performance.

MetaKube: An Experience-Aware LLM Framework for Kubernetes Failure Diagnosis

Existing LLM-based Kubernetes diagnostic systems cannot learn from operational experience, operating on static knowledge bases without improving from past resolutions. We present MetaKube, an experience-aware LLM framework through three synergistic innovations: (1) an Episodic Pattern Memory Network (EPMN) that abstracts diagnostic patterns from historical resolutions and provides confidence-calibrated retrieval for both rapid pattern matching and guided causal exploration, (2) a meta-cognitive controller that dynamically routes between intuitive and analytical pathways based on problem familiarity, optimizing the trade-off between speed and depth, and (3) KubeLLM, a locally-deployable 8B model enhanced through domain-specific post-training on our 7,000-sample Kubernetes Fault Resolution Dataset. Evaluation on 1,873 real-world scenarios demonstrates MetaKube transforms Qwen3-8B from 50.9 to 90.5 points, approaching GPT-4.1 performance while ensuring complete data privacy. EPMN contributes 15.3% improvement through experiential learning, with continuous learning experiments showing progressive gains as the system accumulates operational knowledge. The source code and related resources are available at https://github.com/MetaKube-LLM-for-Kubernetes-Diagnosis/MetaKube.

Agentic AI for Scalable and Robust Optical Systems Control

We present AgentOptics, an agentic AI framework for high-fidelity, autonomous optical system control built on the Model Context Protocol (MCP). AgentOptics interprets natural language tasks and executes protocol-compliant actions on heterogeneous optical devices through a structured tool abstraction layer. We implement 64 standardized MCP tools across 8 representative optical devices and construct a 410-task benchmark to evaluate request understanding, role-aware responses, multi-step coordination, robustness to linguistic variation, and error handling. We assess two deployment configurations--commercial online LLMs and locally hosted open-source LLMs--and compare them with LLM-based code generation baselines. AgentOptics achieves 87.7%--99.0% average task success rates, significantly outperforming code-generation approaches, which reach up to 50% success. We further demonstrate broader applicability through five case studies extending beyond device-level control to system orchestration, monitoring, and closed-loop optimization. These include DWDM link provisioning and coordinated monitoring of coherent 400 GbE and analog radio-over-fiber (ARoF) channels; autonomous characterization and bias optimization of a wideband ARoF link carrying 5G fronthaul traffic; multi-span channel provisioning with launch power optimization; closed-loop fiber polarization stabilization; and distributed acoustic sensing (DAS)-based fiber monitoring with LLM-assisted event detection. These results establish AgentOptics as a scalable, robust paradigm for autonomous control and orchestration of heterogeneous optical systems.

AgentLAB: Benchmarking LLM Agents against Long-Horizon Attacks

LLM agents are increasingly deployed in long-horizon, complex environments to solve challenging problems, but this expansion exposes them to long-horizon attacks that exploit multi-turn user-agent-environment interactions to achieve objectives infeasible in single-turn settings. To measure agent vulnerabilities to such risks, we present AgentLAB, the first benchmark dedicated to evaluating LLM agent susceptibility to adaptive, long-horizon attacks. Currently, AgentLAB supports five novel attack types including intent hijacking, tool chaining, task injection, objective drifting, and memory poisoning, spanning 28 realistic agentic environments, and 644 security test cases. Leveraging AgentLAB, we evaluate representative LLM agents and find that they remain highly susceptible to long-horizon attacks; moreover, defenses designed for single-turn interactions fail to reliably mitigate long-horizon threats. We anticipate that AgentLAB will serve as a valuable benchmark for tracking progress on securing LLM agents in practical settings. The benchmark is publicly available at https://tanqiujiang.github.io/AgentLAB_main.

RASA: Routing-Aware Safety Alignment for Mixture-of-Experts Models

Mixture-of-Experts (MoE) language models introduce unique challenges for safety alignment due to their sparse routing mechanisms, which can enable degenerate optimization behaviors under standard full-parameter fine-tuning. In our preliminary experiments, we observe that naively applying full-parameter safety fine-tuning to MoE models can reduce attack success rates through routing or expert dominance effects, rather than by directly repairing Safety-Critical Experts. To address this challenge, we propose RASA, a routing-aware expert-level alignment framework that explicitly repairs Safety-Critical Experts while preventing routing-based bypasses. RASA identifies experts disproportionately activated by successful jailbreaks, selectively fine-tunes only these experts under fixed routing, and subsequently enforces routing consistency with safety-aligned contexts. Across two representative MoE architectures and a diverse set of jailbreak attacks, RASA achieves near-perfect robustness, strong cross-attack generalization, and substantially reduced over-refusal, while preserving general capabilities on benchmarks such as MMLU, GSM8K, and TruthfulQA. Our results suggest that robust MoE safety alignment benefits from targeted expert repair rather than global parameter updates, offering a practical and architecture-preserving alternative to prior approaches.

Orthogonal Hierarchical Decomposition for Structure-Aware Table Understanding with Large Language Models

Complex tables with multi-level headers, merged cells and heterogeneous layouts pose persistent challenges for LLMs in both understanding and reasoning. Existing approaches typically rely on table linearization or normalized grid modeling. However, these representations struggle to explicitly capture hierarchical structures and cross-dimensional dependencies, which can lead to misalignment between structural semantics and textual representations for non-standard tables. To address this issue, we propose an Orthogonal Hierarchical Decomposition (OHD) framework that constructs structure-preserving input representations of complex tables for LLMs. OHD introduces an Orthogonal Tree Induction (OTI) method based on spatial--semantic co-constraints, which decomposes irregular tables into a column tree and a row tree to capture vertical and horizontal hierarchical dependencies, respectively. Building on this representation, we design a dual-pathway association protocol to symmetrically reconstruct semantic lineage of each cell, and incorporate an LLM as a semantic arbitrator to align multi-level semantic information. We evaluate OHD framework on two complex table question answering benchmarks, AITQA and HiTab. Experimental results show that OHD consistently outperforms existing representation paradigms across multiple evaluation metrics.

Enhancing Medical Large Vision-Language Models via Alignment Distillation

Medical Large Vision-Language Models (Med-LVLMs) have shown promising results in clinical applications, but often suffer from hallucinated outputs due to misaligned visual understanding. In this work, we identify two fundamental limitations contributing to this issue: insufficient visual representation learning and poor visual attention alignment. To address these problems, we propose MEDALIGN, a simple, lightweight alignment distillation framework that transfers visual alignment knowledge from a domain-specific Contrastive Language-Image Pre-training (CLIP) model to Med-LVLMs. MEDALIGN introduces two distillation losses: a spatial-aware visual alignment loss based on visual token-level similarity structures, and an attention-aware distillation loss that guides attention toward diagnostically relevant regions. Extensive experiments on medical report generation and medical visual question answering (VQA) benchmarks show that MEDALIGN consistently improves both performance and interpretability, yielding more visually grounded outputs.

Synthetic Voices, Real Threats: Evaluating Large Text-to-Speech Models in Generating Harmful Audio

Modern text-to-speech (TTS) systems, particularly those built on Large Audio-Language Models (LALMs), generate high-fidelity speech that faithfully reproduces input text and mimics specified speaker identities. While prior misuse studies have focused on speaker impersonation, this work explores a distinct content-centric threat: exploiting TTS systems to produce speech containing harmful content. Realizing such threats poses two core challenges: (1) LALM safety alignment frequently rejects harmful prompts, yet existing jailbreak attacks are ill-suited for TTS because these systems are designed to faithfully vocalize any input text, and (2) real-world deployment pipelines often employ input/output filters that block harmful text and audio. We present HARMGEN, a suite of five attacks organized into two families that address these challenges. The first family employs semantic obfuscation techniques (Concat, Shuffle) that conceal harmful content within text. The second leverages audio-modality exploits (Read, Spell, Phoneme) that inject harmful content through auxiliary audio channels while maintaining benign textual prompts. Through evaluation across five commercial LALMs-based TTS systems and three datasets spanning two languages, we demonstrate that our attacks substantially reduce refusal rates and increase the toxicity of generated speech. We further assess both reactive countermeasures deployed by audio-streaming platforms and proactive defenses implemented by TTS providers. Our analysis reveals critical vulnerabilities: deepfake detectors underperform on high-fidelity audio; reactive moderation can be circumvented by adversarial perturbations; while proactive moderation detects 57-93% of attacks. Our work highlights a previously underexplored content-centric misuse vector for TTS and underscore the need for robust cross-modal safeguards throughout training and deployment.